Grid wall structure is a new type of lateral force resistance system obtained by grid steel plate wall. It has the advantages of good seismic performance, small welding workload, convenient component processing and transportation, convenient construction and installation, etc., which meets the current policy requirements of vigorously developing prefabricated steel structure. At present, the research of grid wall structure mainly focuses on the mechanical properties, but it has not been applied in practical engineering design. In order to explore the feasibility of its application in practical projects, the steel frame-steel plate shear wall structure of Building 9 of the affordable housing construction project (Phase II) was used as the background for structural layout and design. The structural calculation model was established in YJK and MIDAS/Gen software, and the overall structure was carried out under the same technical parameters and load conditions Analysis, component bearing capacity checking calculation and key node design and analysis. In YJK and MIDAS/Gen, the elastic analysis of steel frame-grid wall structure is carried out, and the overall index of the structure is obtained, and the overall index is compared with that of the original steel frame-steel plate shear wall structure. The results show that: steel frame-grid wall structure lateral force members are arranged along the plane and elevation rules, and the indexes obtained by the two software are close and meet the JGJ 99-2015 “High-rise civil building steel structure Technical Regulations” and GB 50011-2010 “Building seismic design Code” requirements, although its side stiffness is slightly lower than the steel frame-steel plate shear wall structure, but the steel mesh wall with steel and welding engineering amount are lower than the corresponding steel plate shear wall. When checking the bearing capacity of the steel members, because the calculation length algorithm of the T-shape steel members of the steel mesh wall is not clear, it is impossible to use the first-order elastic analysis method to calculate the stability of the members, so the direct analysis method is used to check the members, considering the initial defects of the whole and the initial defects of the members, and the nonlinear analysis under each load combination. The results show that: the strength-stress ratio of all steel members All of them are less than 1.0, and the bearing capacity of the components meets the requirements of GB 50017-2017 “Steel Structure Design Standard”. As a connecting member between T-shaped steel and edge members, the fishplate plays an important role in the energy dissipation performance of the steel mesh wall. In order to ensure the reliability of the connection, the mechanical properties of the fishplate are deeply analyzed. A refined finite element model of the three-layer local substructure of the steel mesh wall is established in the finite element software ABAQUS, and the internal force of the column top and the load on the beam under the action of the load envelope combination is applied The analysis results show that the fishplate, T-shaped steel members and edge members do not yield under the design load. When the fishplate yields under the lateral loading, most T-shaped steel members, beam ends and the compression side of the bottom column foot have already yielded, meeting the design requirements of “strong joints and weak members”.